We used temporal GRACE solutions to better understand infiltration, recharge, connectivity, groundwater flow, preferred pathways, and impediments for groundwater flow for large aquifers in arid and semi-arid parts of the world. In addressing the above-mentioned parameters, special attention/efforts were dedicated to carefully selecting simple hydrologic systems that address the investigated parameters for large aquifers (infiltration, recharge, mass flow, impediments, response to climate change, and utilization) with certainty. Complex hydrologic systems that render multiple interpretations for the observed temporal GRACE observations were avoided.